Hetero-substituted sulfonamido-benzamide hybrids as glucokinase activators: Design, synthesis, molecular docking and <i>in</i>-<i>silico</i> ADME evaluation

A series of hetero-substituted sulphonamido-benzamide derivatives which can activate glucokinase (GK) were synthesized and screened in-vitro using Human GK activation assay and in-vivo following oral glucose tolerance test (OGIT) assays. All the molecules were docked into the active site of 1V4S rec...

Descripción completa

Detalles Bibliográficos
Autores principales: Khadse, Saurabh C., Amnerkar, Nikhil D., Dighole, Krushna S., Dhote, Ashish M., Patil, Vikas R., Lokwani, Deepak K., Ugale, Vinod G., Charbe, Nitin B., Chatpalliwar, Vivekanand A.
Formato: Artículo (Article)
Idioma:Inglés (English)
Publicado: 2025
Materias:
Glucokinase
Glucokinase activator
Sulfonamido-benzamides
Docking
ADME
03 Good Health and Well-being
03 Salud y bienestar
Acceso en línea:https://repositorio.uc.cl/handle/11534/100314

Internet

https://repositorio.uc.cl/handle/11534/100314

Ejemplares similares