Quinazolin-4-one derivatives lacking toxicity-producing attributes as glucokinase activators: design, synthesis, molecular docking, and <i>in-silico</i> ADMET prediction

Background A small library of quinazolin-4-one clubbed thiazole acetates/acetamides lacking toxicity-producing functionalities was designed, synthesized, and evaluated for antidiabetic potential as glucokinase activators (GKA). Molecular docking studies were done in the allosteric site of the human...

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Detalles Bibliográficos
Autores principales: Khadse, Saurabh C., Amnerkar, Nikhil D., Dave, Manasi U., Lokwani, Deepak K., Patil, Ravindra R., Ugale, Vinod G., Charbe, Nitin B., Chatpalliwar, Vivekanand A.
Formato: Artículo (Article)
Idioma:Inglés (English)
Publicado: 2025
Materias:
Glucokinase activator
Glucokinase
Quinazolinones
Docking
03 Good Health and Well-being
03 Salud y bienestar
Acceso en línea:https://repositorio.uc.cl/handle/11534/100755

Internet

https://repositorio.uc.cl/handle/11534/100755

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